Sickle Cell Anemia Essay Example | Topics and Well Written Essays - 1500 words

Sickle Cell Anemia - Essay Example Each cell of a human body consists of a nucleus. All the genetic material required for the physical characteristics of a human being are present in the 23 chromosomes located inside the nucleus. A single unit of a DNA is called a gene. A gene provides us with the directions required for synthesizing a protein and these proteins are responsible for our traits. Each gene consists of a specific order of nucleotides and these nucleotides dictate the order of amino acids which in turn form chains and links to form proteins. These sequences of amino acids are very important because they are responsible for the shape, structure and characteristics of a protein. Any change in this sequence is called a mutation and the effects could be dreadful. Change in this sequence could cause the characteristics of a protein to change completely. Mutation is basically the spontaneous change in the structure of a gene or chromosome. There are many types of mutations and they could either be beneficial or harmful. This type of mutation is an example of a point mutation or a missense mutation, and is obviously extremely harmful, if the gene occurs in a homozygotic form. It occurs in the beta globin gene (HBB) which is present in the 11th chromosome. The HBB gene is responsible for normal blood production. The point mutation causes the beta hemoglobin molecule to convert the GAG codon into a GUG codon by transcription i.e. it encodes the amino acid valine rather than the seventh amino acid, glutamic acid. Valine is hydrophobic (water hating) causing the hemoglobin molecule to bend inwards, causing it to become sickle shaped. There are no other changes in the structure. The synthesis of any protein is a two-step process. Firstly the instructions in the gene, present in the DNA, are copied onto a messenger RNA (mRNA) with the help of RNA polymerase. The synthesis of the mRNA is a complex process. This stage is known as transcription. In this stage, the RNA polymerase breaks the bonds of the double helical molecule of DNA and with the help of base pairing, different RNA nucleotides are added one at a time. To understand the concept of base pairing, one needs to understand the structure of RNA first. Each RNA molecule consists of a nitrogenous base, sugar and a phosphate molecule. But unlike DNA, RNA is single stranded. During transcription, each DNA nucleotide is paired with a complimentary RNA nucleotide. The complimentary base pairs are as follows: Guanine with Cytosine Thymine(DNA) pairs with Adenine (RNA) Adenine (DNA) pairs with Uracil(RNA) One of the basic differences between DNA and RNA is of the nitrogenous bases. In place of Thymine, RNA contains Uracil. This method of base pairing ensures that the correct sequence of nucleotides, present in the DNA, is copied onto the mRNA chain. (Gary H. Perdew) These instructions consist of the sequence in which the amino acids should be linked together to form the protein. In this case, the new mRNA formed at the 11th c hromosome is encoded with the mutant code. Then the information on the mRNA bases is translated by the ribosomes so that they can place amino acids in the given order to form the protein that was coded for by the gene in this case, the beta s globin. Three nucleotides in an mRNA molecule are the code for one amino acid. This set of nucleotides is known as a codon. This sequence of codons is actually the code for the sequence of amino acids in a protein. Because of the point mutation the HBB gene

Statistics assignment Project Example | Topics and Well Written Essays - 500 words

Assignment - Statistics Project Example where X1 , X2 , X3 are the three test scores and X is the final score. Assume that your test scores are (integer) values between 1 and 10 with equal probability 1/10, independently from each other. What is the probability mass function of the final score? Q6. (10) The metro train arrives at the station, always on time, near your home every quarter hour starting at 6:00 AM. You walk into the station every morning between 7:10 and 7:30 AM, with the time in this interval being a uniform random variable. The mean is the most commonly-used measure of central tendency in a distribution. The mean is valid only for interval data. Since it uses the values of all of the data points in the populations or sample, the mean is influenced by outliers that may be at the extremes of the data set. On the other hand, the median can be determined for ordinal data as well as interval data. Unlike the mean, the median is not influenced by outliers at the extremes of the data set. Q8. (10) A system consists of 3 components arranged in series. The lifetime (in days) of each component follows approximately an exponential distribution with a mean lifetime of 100 days. The lifetimes of the components are independent. Where p1(x, ï  ¬), p2(x, ï  ¬), p3(x, ï  ¬) are three independent exponential distributions in parallel. After some algebra and if we take q as any of the three independent exponential distributions, q = p1 or q = p2, q = q3, q = ï  ¬

Evaluate the Decision Making Process Assignment

Evaluate the Decision Making Process - Assignment Example Despite the forth coming problems, an effective and true decision, which is taken at right time, may also saves many of the important organizational resources (Ingram, 2010). According to the experts, the basic goal of the decision making process is to achieve some desired and set goals and objectives and avoid negative and poor consequences (Krehbiel, 2012). The firms’ managers always try to take a right decision at right time so that they can support the other organizational activities and thus giving a better output productivity. When any decision is taken in the organizational perspective than for sure it will help the organizational mangers but at the same time there can be some good or best decisions which not only support the organizational system but also add up to the efficiency of the organizational activities and the operations (Krehbiel, 2012). The process of decision making is a systematic progression which actually works in a step by step series. The process may starts with the recognition of the problem. This can be happen when the manager or any of workers may predict or forecast any possible problem or contingency in the very short run for the organization (Heckman & Crowston, 2011). Here it is not necessary that there will be a prediction of the problem rather the manger may come to know about the problem when they are badly struck in it. The critical point is that the manger or the firm mya truly identify the problem in the situation. Many of the mangers may get confuse between the actual problem and its symptoms. In most of the situation, the symptoms are very clear but the mangers may not track the problem exactly. Therefore, at first step the real identification of the problem is very important (Heckman & Crowston, 2011). Now in this situation the managers must carefully analyze all the possible factors and the reasons, so that they may come to know about the difference between the symptoms and the actual problem

Attempts to Repeal the Laws of Supply and Demand - The Market Strikes Assignment

Attempts to Repeal the Laws of Supply and Demand - The Market Strikes Back - Assignment Example Ultimately, the demand-supply coordinates are violated, hence shifting the curve principles outside the principle factors. The free market prices are fixed by the demand-supply laws; however when the law is not adhered to then this leads to what is known as cost distortion. While governments would impose price controls or create policies that would create crushing relationship between supply and demand, this would artificially distract the market mechanism. Hence, the cost dilemma would alter the relevance of the commodities and may lead to specific losses and out- of-the- market experiences. The market’s response to this would be termed in a balanced experience. The price in such instance would not fall below a specific level, known as â€Å"Price Floor’ and an attempt to repeal this would constitute to ‘product vacuum’ and would create scarcity and eventually imbalances in demand-supply

SWOT analysis Essay Example | Topics and Well Written Essays - 250 words

SWOT analysis - Essay Example Kathmandu Holdings Limited is an organisation committed to providing quality clothing and equipment for travel and adventure through its operated company stores. The major strength of the organisation lies in its capability to develop its brand and value which are satisfactory to the customer. This is a result of its vertically integrated business model which gives it control of its brand and products. This also allows it to achieve both a wholesale and retail margin. The major notable weakness for Kathmandu is that its success is over reliant on its reputation and branding. Unexpected issues can damage this reputation which is a weakness since there are no measures in place to counter this development should it happen. The opportunity for the company is that it has a network of company operated retail stores which makes it easy to gather information about the needs and wants of the customers. The other opportunity is that it has significantly invested in its IT systems to support its future growth plans. The other opportunity is that the organisation is strategically positioned to deliver attractive financial results to its shareholders and it allows public investors the opportunity to invest in business successfully. Its stance on brand awareness is another opportunity behind its success story in the market for outdoor travelling clothes and equipment. Likewise, this organisation does not operate in isolation from other firms. Of significant importance in this case is damage to Kathmandu’s brand as well as aggressive competition. This makes it a bit challenging for the organisation to maintain its competitive advantage as well as its dominance in the market with regards to the quality of its products that have greatly contributed to its success over the last years. The other threat is the risk associated with investing in the stock market generally where the management may not be able to

Marketing Management. Fast food Assignment Example | Topics and Well Written Essays - 1750 words

Marketing Management. Fast food - Assignment Example In Canada fast food restaurant include Boston Pizza, Tim Horton and Swiss Chalet. In the UK fast food restaurants include included Easy Pizza, and Pizza Express. In this market the restaurant form chains which are in most cases centrally controlled, this restaurants have been criticised in the past that excess consumption of these foods will lead to obesity, the direct advertisements to children, the reduction of local cuisines and their lack to provide employment. Consumer behaviour is changing and the fast food industry is loosing market share to other restaurants that produce expensive meals to consumers, also the campaign against the consumption of these fast foods has led to a decrease in consumption. Advertising in the fast food restaurant is through television commercials, the print media, billboards and events sponsoring. Recently this food restaurant are now changing to internet advertising due to increased criticisms on television and media, Branding includes clothing, direct signs and posters. McDonald has sponsored the Olympic Games, FIFA world cup and NASCAR teams. Advertising plays a major role in marketing a product; advertising informs consumers on existing products, communicates the information about a product, stimulates the distribution of a product, increases product usage and finally builds brand preferences and loyalty through constant and consistent promotional campaigns. Fast food advertising in 2001 amounted to 635 million dollars for McDonald, 298 million dollars for Burger King, 179 million dollars for Tacos Bell and 148 million dollars for Pizza Hut. (http://www.ijbnpa.org/content/pdf/1479-5868-1-3.pdf) According to the fast food industry statistics the fast food industry is losing popularity due the constant campaigns, the campaigns are usually based on the fact that the food they produce cause obesity, the advertisement of junk food to children and this has led to countries introducing strict limitation on fast food advertisement and this has made them to advertise through the internet as an alternative to reach their customers. We there fore analyse the MacDonald restaurant to view their strategic planning on market throughout its historical development from a small restaurant to a multinational restaurant. Mc Donald Fast Food Restaurant. Mc Donald is the largest fast food restaurant in the world. It has dominated the American market and the rest of the world. The restaurant has many branches all over the world and they are similar in their services, staff uniform, menu, packaging and services with a smile. The principle of this restaurant is efficiency, calculability, uniformity and control through automation. It was founded in 1940 by Dick and Mac McDonald. This company has branches in 199 countries and serves close to 5 million customers dairy. In 2005 report, the company had a total of 45,777 employees, in the same year total revenue amounted to 20.466 billion US dollars and the net income to the restaurant amounted to 2.602 billion US dollars. The volume of food used every year are 32,000 tonnes of beef, 21,500 tonnes of chicken, 100 million eggs and 7,250 tonnes of cheese just to mention a few. Mc Donald and Dick ventured into the food business in 1937 by opening a hotdog stand in Arcadia California, they later expanded their business and in 1940

WICKED ANALYSIS PAPER Essay Example | Topics and Well Written Essays - 750 words

WICKED ANALYSIS PAPER - Essay Example When this is coupled with her high intelligence and her activist aspirations, the conventional society within the book perceives her as evil, eventually dubbing her The Wicked Witch of the West. Because she can be seen as having a difference in the way she looks and because her belief systems do not agree with the current trends in government, Elphaba is viewed from her society as an instrument for evil. Author Gregory Maguire has given Elphaba many attributes beyond her green skin that make her different than the people around her. She was born with sharp teeth and her first act after the experience of being born was to bite off the finger of a fishwife (20). Maguire writes of her as she imitates a dragon during her infancy that â€Å"Her green skin made her more persuasive as if she were a dragon child. She roared again - â€Å"Oh sweetheart don’t† sad Frex - and she peed on the floor, and sniffed her urine with satisfaction and disgust.† (44). In developing the many aspects of her personality with stories that support her differences to the social setting around her, she is being set apart for aspects of physical representation that foreshadow differences in her social assimilation that will eventually turn her society against her. human beings themselves judge that conductâ€Å" (48). For Elphaba, this begins with her physical appearance. After this initial physical identifying characteristic is developed by Maguire, her defining moments become more deeply established in the disagreement she develops with societal decisions that she feels leave others in a disadvantaged position. The government had put restrictions on Animals - creatures who were capable of speaking and thinking in the same way as humans. In a compassionate stance, she begins to act on their behalf, behaving as a revolutionary. Because of her actions, her character begins to